Cilnidipine is a 4 th generation dihydropyridine calcium channel blocker approved recently for the treatment of essential hypertension
Edema is a frequent manifestation of systemic illness resulting in maldistribution of total body water
Amlodipine (5 mg UID) increased leg weight without modifying postural vasoconstriction (the percent skin blood flow decrease from horizontal to dependent position), which
6% of amlodipine users
Swelling caused by amlodipine does not usually respond to treatment with diuretics (such as furosemide) because it is caused by changes in capillary pressure that
Increasing the dose of amlodipine has increased the likelihood of having pedal edema, but it is not statistically significant (odds ratio = 2
Amlodipine is a fourth generation dihydropyridine derivative calcium channel blocker, mainly used in the treatment of hypertension, angina and certain other cardiac disorders
Participant Recruitment Weight-stable women of nonchildbearing potential and men between 50 and 75 years of age with a body mass index >22 kg/m 2 and ≤35
6% of patients discontinued the treatment amid pedal edema as compared to 9
It may be apt to call Amlodipine induced edema as a form of local venous edema
Rates of reported peripheral edema induced by single DHPCCBs treatment ranged from 0% to 77
Quantification of pedal edema during treatment with S (−)-amlodipine nicotinate versus amlodipine besylate in female Korean patients with
Moreover, it has been proposed as an alternative anti-hypertensive for patients with amlodipine-induced edema
66%) in cilnidipine group presented with pedal edema during the study period
Thus, drug-induced peripheral oedema is underrecognized and misdiagnosed, frequently leading to a prescribing cascade
Of 30 patients in the amlodipine group, 19 patients presented with pedal edema (63
This drug is expected to produce a lesser incidence of pedal oedema, as compared to Amlodipine, based on the limited data available from clinical trials
[] Although it is a self-limited and relatively minor adverse effect in the most affected patients, amlodipine-induced edema can occasionally be severe, even progressing to anasarca
Failing conventional treatment Case Report on Amlodipine Induced Pitting Type Pedal Edema
3
Amlodipine is a fourth generation dihydropyridine derivative calcium channel blocker, mainly used in the treatment of hypertension, angina and certain other cardiac disorders
Cilnidipine has been reported to have more beneficial effects on proteinuria progression in hypertensive patients than Amlodipine, an L-type CCB